Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

摘要: The cellular receptor for urokinase, uPAR, localizes its ligand, uPA, and thereby the plasminogen activation, to cell surface. uPA also cleaves liberating ligand-binding domain I, inactivates binding potential of uPAR both vitronectin. uPA-catalyzed cleavage is fast on surface, when bound a neighboring molecule. can be shed from However, soluble form cannot cleaved by uPA. Glycolipid-anchored forms intact, uPAR(I-III), receptor, uPAR(II-III) uPAR(I), have been identified in tissue body fluids. It well-established, that total amount all strong prognostic marker different types cancer. Using immunoassays, measuring individual forms, has revealed are even stronger markers diagnostic utility. This review will focus mechanism functional consequences, as well clinical applicability forms.