Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells.

作者: Hiroshi Yazawa , Bernd Zimmermann , Yoshiko Asami , Jean-Pierre Bernimoulin

DOI: 10.1902/JOP.2005.76.2.295

关键词:

摘要: … osteopontin content after 7 days and calcium contents after … the culture flasks by Trypsin-EDTA and the cell suspension was … However, it is hard to conclude that orally taken simvastatin …

参考文章(34)
Jean-Pierre Desager, Yves Horsmans, Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Clinical Pharmacokinectics. ,vol. 31, pp. 348- 371 ,(1996) , 10.2165/00003088-199631050-00003
N. Nojima, M. Kobayashi, M. Shionome, N. Takahashi, T. Suda, K. Hasegawa, Fibroblastic cells derived from bovine periodontal ligaments have the phenotypes of osteoblasts. Journal of Periodontal Research. ,vol. 25, pp. 179- 185 ,(1990) , 10.1111/J.1600-0765.1990.TB01041.X
Moon-Il Cho, Naoki Matsuda, Wen-Lang Lin, Alice Moshier, P. R. Ramakrishnan, In vitro formation of mineralized nodules by periodontal ligament cells from the rat. Calcified Tissue International. ,vol. 50, pp. 459- 467 ,(1992) , 10.1007/BF00296778
Keizo Ohnaka, Seiko Shimoda, Hajime Nawata, Hiroaki Shimokawa, Kozo Kaibuchi, Yukihide Iwamoto, Ryoichi Takayanagi, Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochemical and Biophysical Research Communications. ,vol. 287, pp. 337- 342 ,(2001) , 10.1006/BBRC.2001.5597
Masako Sugiyama, Tohru Kodama, Kyoko Konishi, Keiichi Abe, Sumio Asami, Shinzo Oikawa, Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochemical and Biophysical Research Communications. ,vol. 271, pp. 688- 692 ,(2000) , 10.1006/BBRC.2000.2697
P. R. Ramakrishnan, W. -L. Lin, J. Sodek, M. -Il Cho, Synthesis of noncollagenous extracellular matrix proteins during development of mineralized nodules by rat periodontal ligament cells in vitro. Calcified Tissue International. ,vol. 57, pp. 52- 59 ,(1995) , 10.1007/BF00298997
Michael R. Thylin, Jay C. McConnell, Marian J. Schmid, Ryon R. Reckling, Junu Ojha, Indraneel Bhattacharyya, David B. Marx, Richard A. Reinhardt, Effects of Simvastatin Gels on Murine Calvarial Bone Journal of Periodontology. ,vol. 73, pp. 1141- 1148 ,(2002) , 10.1902/JOP.2002.73.10.1141
Bernd Zimmermann, Degeneration of osteoblasts involved in intramembranous ossification of fetal rat calvaria. Cell and Tissue Research. ,vol. 267, pp. 75- 84 ,(1992) , 10.1007/BF00318693
Toyonobu Maeda, Ayako Matsunuma, Tetsuya Kawane, Noboru Horiuchi, Simvastatin Promotes Osteoblast Differentiation and Mineralization in MC3T3-E1 Cells Biochemical and Biophysical Research Communications. ,vol. 280, pp. 874- 877 ,(2001) , 10.1006/BBRC.2000.4232
G Mundy, R Garrett, S Harris, J Chan, D Chen, G Rossini, B Boyce, M Zhao, Gl Gutierrez, Stimulation of Bone Formation in Vitro and in Rodents by Statins Science. ,vol. 286, pp. 1946- 1949 ,(1999) , 10.1126/SCIENCE.286.5446.1946