Parkinson’s Disease: Alpha-Synuclein and Neurodegeneration
作者： M. Goedert
DOI: 10.1016/B978-008045046-9.00512-X
关键词:
摘要: Parkinson’s disease, the most common movement disorder, is characterized by nerve cell loss in substantia nigra and other brain regions presence of filamentous α-synuclein inclusions bodies processes (also known as Lewy neurites). Similar define body dementias, well a number other, less neurodegenerative diseases. Some inherited forms disease dementias are caused missense mutations gene or overproduction wild-type α-synuclein, establishing that dysfunction sufficient to cause dementias.
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