Hepatitis C core antigen in Polish blood donors.
作者： Magdalena Letowska , Ewa Brojer , Maria Mikulska , Agnieszka Gronowska , Aleksandra Rosiek
DOI: 10.1111/J.1537-2995.2004.03340.X
关键词:
摘要: BACKGROUND: The goal of this study was to evaluate the feasibility adopting HCV core antigen ELISA (HCVcAg) for routine screening Polish blood donors. STUDY DESIGN AND METHODS: A total 133,279 donor samples were tested by ORTHO HCVcAg. All repeatedly reactive (RR) neutrali-zation test confirmation, RIBA anti-HCV, and Cobas Amplicore RNA. donations ALT level. RESULTS: HCVcAg specificity 99.94 percent. In total, 1499 (1.12%) initially 124 (0.09%) RR. Antibodies found in 22 out donors RNA detected 19 22. 10 HCV-RNA-positive donors, neutralization positive. Among 102 RR/anti-HCV-negative there 6 neutralization-test-positive indivi-duals, all Elevated level observed one them. During follow-up studies three RR/HCV-RNA-positive sero-convertion 5 7 weeks after initial HCVcAg-positive result. all, results became negative once antibodies detected. CONCLUSION: proved be feasible Blood Transfusion Service. Six identified. calculated residual risk preseroconversion window 45 per million. Mandatory testing every plasma donation or recommended as January 2, 2002.
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