Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: a study of 64 patients

摘要: We report here the results of polymerase chain reaction (PCR) for bcr-abl transcript and clinical details derived from 64 chronic myelogenous leukemia (CML) patients after allogeneic bone marrow transplantation (BMT). A total 139 samples (2 to 220 weeks BMT) were analyzed was detected in 99 52 patients. Patients defined as early negative (EN) if they had > or = 1 PCR result positive year post-BMT (n 21). Among LP patients, only two hematologic/cytogenetic (clinical) relapse. Another 19 remained remission 7 130 analysis transcript, including 5 who persistent detectable even 2 years BMT. To estimate relationship between data residual EN are compared with However, no studied significantly associated positivity. If phase compared, t-test showed significant correlation leukocyte count just before BMT sustained (P < .05). These suggest that positivity is frequently observed CML sustain BMT, without being predictive imminent Tumor burden at time may play an important role latency