Models of dystonia: an update

摘要: Abstract Although dystonia represents the third most common movement disorder, its pathophysiology remains still poorly understood. In past two decades, multiple models have been generated, improving our knowledge on molecular and cellular bases of this heterogeneous group disorders. short survey, we will focus recently generated novel DYT1 dystonia, form genetic, “isolated” dystonia. These clearly indicate existence signaling pathways affected by protein mutation causative torsinA, paving way for potentially multiple, targets pharmacological intervention.