IsHelicobacter pyloriinfection associated with glycemic control in diabetics?

摘要: AIM: To investigate whether Helicobacter pylori (H. pylori) infection is associated with glycemic control and hyperglycemia modified by eradication therapy. METHODS: The databases of PubMed, Cochrane Library, Chinese BioMedicine Web Base Science Technology Journals were searched from inception to June 2014. Studies examining the association between H. and⁄or effect treatment on in diabetic humans eligible for inclusion. Meta-analyses conducted using Review Manager software version 5.2. outcome measures are presented as weighed mean differences (WMDs) 95% confidence intervals (CIs). Statistical heterogeneity was assessed Cochran Q test I2 statistic. RESULTS: A total 21 relevant publications identified. meta-analysis 11 studies 513 patients diabetes mellitus (DM) showed significantly lower glycosylated hemoglobin (HbA1c) levels pylori-negative than pylori-positive DM participants (WMD = 0.43, 95%CI: 0.07-0.79; P 0.02). In children adolescents type 1 (T1DM), there a positive HbA1c level 0.35, 0.05-0.64; 0.02), but no difference those 2 (T2DM, WMD 0.51, -0.63-1.65; 0.38). six 325 T2DM significant fasting plasma glucose 1.20, 0.17-2.23; Eradication did not improve three-month follow-up period (HbA1c decrease: -0.03, 95%CI -0.14-0.08; 0.57; -0.06, -0.36-0.23; 0.68). Glycemic better T1DM who reinfected (HbA1c: 0.72, 0.32-1.13: 0.00). CONCLUSION: poorer patients, may short-term period.