Community and Patient Values for Preventing Herpes Zoster

摘要: The US Advisory Committee on Immunization Practices has recently recommended a new vaccine against herpes zoster (shingles) for routine use in adults aged ≥60 years. However, estimates of the cost effectiveness this vary widely, part because gaps data value preventing zoster. Our aims were to (i) generate comprehensive information range outcomes zoster; (ii) compare these values among community members and patients with shingles post-herpetic neuralgia (PHN); (iii) identify clinical demographic characteristics that explain variation values. Community drawn from nationally representative survey research panel (n = 527) completed an Internet-based using time trade-off willingness-to-pay questions series scenarios described cases varying pain intensities (on scale 0 10, where represents no 10 worst imaginable pain) duration (30 days 1 year). Patients 382) or PHN 137) [defined as having symptoms =90 days] two large healthcare systems telephone interviews similar also answered about their current experience We constructed generalized linear mixed models evaluate associations between characteristics, length intensity health states In questions, offered mean 89 (95% CI 24, 182) discounted avoid least severe scenario (pain level 3 month) 162 88, 259) most 8 12 months). Compared shingles, traded more low-severity but numbers high-severity scenarios. PHN, fewer multivariate analyses, older age was only characteristic significantly associated higher $US450 203, 893) month $US1384 873, 2050) [year 2005 values] months. less money than either both low- (p-values <0.05 <0.001). models, male gender, income experienced willingness pay When asked assign avoiding own case zoster, those assigned 67 $US2319, while 206 $US18 184. Both monetary maximum individual had experienced, neither pain. believe study provides date individuals place it includes such valuation well would trade substantial amounts even results may differ other studies important differences methods assessing utilities. Consideration patient perspectives is crucial help decision makers fully determine implications policies now available.