作者: Ruben G. Lancestremere , Paul L. Davidson , Laurence E. Earley , Frederick J. O'brien , Solomon Papper
DOI: 10.1172/JCI104649
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摘要: A number of observations in patients with Laennec's cirrhosis dying renal failure-one the conditions sometimes included term "hepatorenal syndrome"-suggest that observed oliguria and nitrogen retention may be secondary to impaired perfusion rather than any lesion parenchyma. First, failure develop great rapidity. In several instances, normal glomerular filtration rate (GFR) had been demonstrated months, weeks, even days before development (1). Second, occur after mild gastrointestinal bleeding, not severe enough produce significant change hematocrit, or abdominal paracentesis, when only five liters fluid are removed (1-3). Minimal bleeding paracente