Wnt-Frizzled Interactions in Xenopus
作者： Herbert Steinbeisser , Rajeeb K. Swain
DOI: 10.1007/978-1-60327-469-2_28
关键词:
摘要: The Wnt signaling cascades are regulatory modules which involved in embryonic patterning, cell differentiation, morphogenesis, and diseases. pathways activated when secreted ligands interact with 7-trans-membrane receptors of the Frizzled (Fz) family. Specific readouts determined by ligand/receptor combinations cellular context. Here we describe two methods for analysis Wnt/Frizzled interactions Xenopus embryos. Physical interaction ligand receptor demonstrated co-immunoprecipitation assays. activation targets animal cap tissue provides a versatile test system activating inhibitory components Wnt/beta -catenin pathway.
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