Hepatic production of erythropoietin in a phenylhydrazine-induced compensated hemolytic state in the rat.

摘要: The relative roles of the kidney and liver as a source Ep in fully compensated hemolytic state were investigated. A anemia was induced rats by injections PHZ over 6-week period. Verification established MCV, MCH, MCHC, BV, PV, CRCV, peripheral reticulocyte counts, bone marrow counts. kidneys livers PHZ-injected subjected to concurrent perfusion at weekly intervals treatment period perfusate assayed for activity. found be principal during earlier stages became increasingly important later progressively compensated. By fifth sixth weeks treatment, when compensated, PHZ-treated Ep. During these last 2 amount recovered from renal effluents no greater than that collected saline-injected rats. data indicate is primary, if not only, higher titers rat long-term treatment.