Growth factor expression in the osteophytes of the human femoral head in osteoarthritis.

摘要: Osteoarthritis is characterized by marked osteophyte formation consisting of new cartilage and bone. Because several growth factors are known to be involved in chondrogenesis osteogenesis, the expression transforming factor-β1 basic fibroblast factor osteophytes human femoral heads osteoarthritis were examined. Transforming messenger ribonucleic acid was detected reverse transcription-polymerase chain reaction. All nine examined expressed acid, whereas one four osteoarthritic none osteonecrotic acid. The extent varied among osteophytes. or analyzed immunohistochemically. localized superficial cells cartilage, but it scarcely degenerative articular cartilage. Basic whole layer There a difference localization, which suggests different roles bone metabolism formation.