Dysplasia of the gut: the diagnosis is harder than it seems.

摘要: Preneoplastic epithelia of the gut have been given several different names, but one most often used is dysplasia. Dysplasias are diagnosed by pathologists, using a set cytologic and architectural features, divided into two grades: low- high-grade. Although definitions imply that all low-grade dysplasias similar (as high-grades), in reality, there significant heterogeneity appearances each grade Thus, separating from high-grade epithelium may be difficult. In addition, features characterize very to many examples epithelial regeneration, so these not readily separable. Such cases classified as being indefinite for For reasons, because implications patient care significant, interpretations biopsies taken dysplasia surveillance considered challenging pathologists. Clinicians must understand nature biopsies, communicate with pathologists who will interpret such obtain an adequate sample mucosa ensure dysplasia, if present, biopsied appropriately diagnosed.