Active viscosupplements for osteoarthritis treatment.

摘要: Abstract Objective Osteoarthritis is a chronic, painful and disabling disease which prevalence increasing in developing countries. Patients with osteoarthritis present reduced synovial fluid viscoelasticity due to reduction concentration molecular weight of hyaluronic acid. Currently, the main treatment used restore compromised rheological properties viscosupplementation by acid injections that can be combined oral anti-inflammatory drugs for pain relief. Combination viscosupplements chemical agents or emerging as new strategy provide double action recovery therapeutic effect bioactive principle. Methods In this review, we latest research on combination active molecules. We conducted literature review articles published different web search engines categorized according molecule introduced into viscosupplement. Results Generally, introduction molecules have shown improve relief although some cytotoxicity has been demonstrated especially non-steroidal drugs. Other such antioxidant modifying reported action. Drug delivery systems could enhance activity encapsulated better control over drug release. Finally, biological approaches use stem cells platelet-rich plasma seem most promising strategies cartilage recovery. Conclusions therapy agents, regenerative therapies outcome terms joint functionality. However, further needed order reach more conclusive results.