Structural Studies of the [Tris(imidazolyl)phosphine]metal Nitrate Complexes {[PimPri,But]M(NO3)}+(M = Co, Cu, Zn, Cd, Hg):  Comparison of Nitrate-Binding Modes in Synthetic Analogues of Carbonic Anhydrase

摘要: X-ray diffraction studies on a series of cationic divalent metal nitrate complexes supported by the tris(1-isopropyl-4-tert-butylimidazolyl)phosphine ligand, {[PimPri,But]M(NO3)}+ (M = Co, Cu, Zn, Cd, Hg), demonstrate that ligand coordination mode is strongly dependent upon metal. With exception for HgII derivative, modes correlate with activities metal-substituted carbonic anhydrases, such only MII-carbonic anhydrases which exhibit significant activity, i.e., Zn and Co species, are those possess asymmetric ligands. This trend supports notion access to unidentate, rather than bidentate, bicarbonate intermediate may be critical requirement anhydrase activity. Interestingly, in group 12 complexes, do not monotonic periodic trend: ...