Effect of experimenter‐delivered and self‐administered cocaine on extracellular β‐endorphin levels in the nucleus accumbens
作者： I. Roth-Deri , A. Zangen , M. Aleli , R. G. Goelman , G. Pelled
DOI: 10.1046/J.1471-4159.2003.01584.X
关键词:
摘要: b-endorphin is an endogenous opioid peptide that has been hypothesized to be involved in the behavioral effects of drugs abuse including psychostimulants. Using microdialysis, we studied effect cocaine on extracellular levels nucleus accumbens, a brain region reinforcing psychostimulant drugs. Experimenter-delivered (2 mg/kg, i.v.) increased immunoreactive attenuated by 6-hydroxy-dopamine lesions or systemic administration D1-like receptor antagonist, SCH-23390 (0.25 i.p.). The release accumbens was mimicked local perfusion dopamine (5 lM) and blocked coadministration (10 lM). Self-administered (1 mg/kg/infusion, also accumbens. In addition, using functional magnetic resonance imaging, found increases regional activity arcuate nucleus. We demonstrate increase following experimenter-delivered self-administered mediated dopaminergic system. These findings suggest activation neurons within nucleus‐nucleus pathway may important neurobiological mechanisms underlying cocaine.
sci-hub.se 参考文章(78)
Jeffrey Alan Gray, The psychology of fear and stress ,(1971)
M. Foster Olive, Heather N. Koenig, Michelle A. Nannini, Clyde W. Hodge, Stimulation of Endorphin Neurotransmission in the Nucleus Accumbens by Ethanol, Cocaine, and Amphetamine The Journal of Neuroscience. ,vol. 21, pp. RC184- RC184 ,(2001) , 10.1523/JNEUROSCI.21-23-J0002.2001
Oleg Aizman, Hjalmar Brismar, Per Uhlén, Eivor Zettergren, Allan I. Levey, Hans Forssberg, Paul Greengard, Anita Aperia, Anatomical and physiological evidence for D 1 and D 2 dopamine receptor colocalization in neostriatal neurons Nature Neuroscience. ,vol. 3, pp. 226- 230 ,(2000) , 10.1038/72929
Louk J. M. J. Vanderschuren, Jan M. van Ree, Mirjam A. F. M. Gerrits, Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine Pharmacological Reviews. ,vol. 51, pp. 341- 396 ,(1999)
Charles W. Bradberry, Rita L. Barrett-Larimore, Peter Jatlow, Susan R. Rubino, Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys The Journal of Neuroscience. ,vol. 20, pp. 3874- 3883 ,(2000) , 10.1523/JNEUROSCI.20-10-03874.2000
L. Churchill, B. P. Roques, P. W. Kalivas, Dopamine depletion augments endogenous opioid-induced locomotion in the nucleus accumbens using bothμ1 andδ opioid receptors Psychopharmacology. ,vol. 120, pp. 347- 355 ,(1995) , 10.1007/BF02311183
William A. Corrigall, Kathleen M. Coen, Opiate antagonists reduce cocaine but not nicotine self-administration Psychopharmacology. ,vol. 104, pp. 167- 170 ,(1991) , 10.1007/BF02244173
Eugene A. Kiyatkin, Elliot A. Stein, Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats Neuroscience Letters. ,vol. 211, pp. 73- 76 ,(1996) , 10.1016/0304-3940(96)12731-2
K NANTWI, E SCHOENER, Cocaine and dopaminergic actions in rat neostriatum. Neuropharmacology. ,vol. 32, pp. 807- 817 ,(1993) , 10.1016/0028-3908(93)90190-E
Satoshi Ikemoto, Jaak Panksepp, The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking Brain Research Reviews. ,vol. 31, pp. 6- 41 ,(1999) , 10.1016/S0165-0173(99)00023-5