A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor
作者： Yoshinori Toshima , Shin-ichi Satoh , Ichiro Ikegaki , Toshio Asano
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摘要: Background and Purpose—The aim of this study was to develop a new model stroke based on endothelial damage thrombotic occlusion in perforating artery, leading small cerebral infarcts neurological deficits rats. Moreover, the neuroprotective efficacy fasudil, rho-kinase inhibitor, investigated model. Methods—Fifty-six male Sprague-Dawley rats were used present study. Rats anesthetized with sodium pentobarbital, 100 μg laurate injected into left internal carotid artery days 1 3. The thrombus induction consequent ischemic brain examined by histopathological analyses deficit scoring posture reflex test. To investigate effects or 10 mg/kg administered intraperitoneally 5 minutes after first injection once daily thereafter following 2 days. Results—One hour laurate, microscopic examination pho...
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