Inflammatory Mediators as Biomarkers in Brain Disorders

摘要: Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable debilitating conditions that result in progressive death of the neurons. The definite diagnosis a neurodegenerative disorder is disadvantaged by difficulty obtaining biopsies thereby to validate clinical with pathological results. Biomarkers valuable indicators for detecting different phases disease prevention, early onset, treatment, progression, monitoring effect pharmacological responses therapeutic intervention. Inflammation occurs diseases, identification validation molecules involved this process could be strategy finding new biomarkers. ideal inflammatory biomarker needs easily measurable, must reproducible, not subject wide variation population, unaffected external factors. Our review summarizes most important inflammation biomarkers currently available, whose specificity utilized identifying distinctive diseases.