HEPATIC DRUG METABOLISM AND PROTEIN MALNUTRITION
作者： Barry H. Rumack , Jordan Holtzman , H. Peter Chase
DOI:
关键词:
摘要: The effect of chronic protein malnutrition on hepatic microsomal drug metabolism, specifically the mixed function oxidases, has been studied. Previous studies have suggested increased hexobarbital sleeping time in malnourished rats. Macaca nemestrina monkeys were fed protein-deficient diets and developed classic features marasmic kwashiorkor with edema weiglmt less than 60% controls. Total heme, phospholipids flavin adenine dinucleotide levels, all which are involved significantly reduced (P vitro to investigate possible alterations their metabolism secondary malnutrition. There no differences kinetic data comparing control group when was expressed per milligram or kilogram body weight. Alterations observed this study, as well previous descriptions altered time, suggest need reduce dosage presence
参考文章(17)
J. L. Holtzman, T. E. Gram, P. L. Gigon, J. R. Gillette, The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells Biochemical Journal. ,vol. 110, pp. 407- 412 ,(1968) , 10.1042/BJ1100407
V. Ramalingaswami, M. G. Deo, Production of periportal fatty infiltration of the liver in the rhesus monkey by a protein-deficient diet. Laboratory Investigation. ,vol. 9, pp. 319- 329 ,(1960)
Philipp Strittmatter, Sidney F. Velick, The isolation and properties of microsomal cytochrome. Journal of Biological Chemistry. ,vol. 221, pp. 253- 264 ,(1956) , 10.1016/S0021-9258(18)65245-7
Alvah H. Phillips, Robert G. Langdon, Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies Journal of Biological Chemistry. ,vol. 237, pp. 2652- 2660 ,(1962) , 10.1016/S0021-9258(19)73803-4
Earl W. Sutherland, Carl F. Cori, Robert. Haynes, Norman S. Olsen, Purification of the hyperglycemic-glycogenolytic factor from insulin and from gastric mucosa. Journal of Biological Chemistry. ,vol. 180, pp. 825- 837 ,(1949) , 10.1016/S0021-9258(18)56702-8
Donough O'Brien, H. Peter Chase, Vijay Kumar, Keith Hammond, Alterations in blood biochemical tests in progressive protein malnutrition. Pediatrics. ,vol. 49, pp. 736- 743 ,(1972)
Vijay Kumar, H. Peter Chase, Progressive protein undernutrition and intestinal enzyme activities in monkeys The American Journal of Clinical Nutrition. ,vol. 25, pp. 485- 489 ,(1972) , 10.1093/AJCN/25.5.485
Philippe L. Gigon, James R. Gillette, Theodore E. Gram, Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates. Molecular Pharmacology. ,vol. 5, pp. 109- 122 ,(1969)
Tsuneo Omura, Ryo Sato, The Carbon Monoxide-binding Pigment of Liver Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 2370- 2378 ,(1964) , 10.1016/S0021-9258(20)82244-3
M. Michael Thaler, Peter R. Dallman, Joseph Goodman, Phenobarbital-induced changes in NADPH-cytochrome c reductase and smooth endoplasmic reticulum in human liver. The Journal of Pediatrics. ,vol. 80, pp. 302- 310 ,(1972) , 10.1016/S0022-3476(72)80599-7