The association between velocity of the center of closest proximity on subchondral bones and osteoarthritis progression

摘要: Altered surface interactions following joint instability may apply novel, damaging loads to articular cartilage. This study measured the velocity of centers closest proximity on subchondral bone surfaces femur and tibia during running in normal unstable canine stifle (knee) joints. The purpose was explore relationship between bones severity cartilage damage. Dynamic biplane radiography used acquire serial knee kinematics [5 control, 18 cranial cruciate ligament (CCL) deficient] treadmill over 2 years. Custom software calculated difference rate at which center translated relative surface. Comparisons were made dogs that developed minor versus major medial compartment damage Major showed a significantly greater increase point from instant paw strike peak 2, 4, 6 months after CCL transaction. implies increased tangential forces associated with compressed region movement (plowing) be mechanism initiates osteoarthritis (OA) development drives OA progression. In future, articulating measurements useful identify patients risk for long-term due instability.