Development and validation of an Arrhythmia-Specific questionnaire in Tachycardia and Arrhythmia (ASTA) with focus on Health-Related Quality of Life

作者: Kristofer Årestedt , Ulla Walfridsson , Anna Strömberg

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摘要: Background: Health-Related Quality of Life (HRQOL) can be negatively affected in patients living with arrhythmias and many experience a pronounced symptom burden. The arrhythmia cause both uncertainty limitations, including interference work, reluctance to perform plan for leisure activities leading self-imposed restrictions daily life situations. There are striving find strategies manage the some this become focus their lives. Treatment options often choice between pharmaceuticals radiofrequency ablation (RFA) where RFA is an option arrhythmia-patients cured. In care it great importance combine objective examinations patient-reported outcomes (PROs) achieve patient’s own experiences treatment efficacy Aims: overall aims thesis were assess burden HRQOL develop validate arrhythmia-specific questionnaire, suitable most arrhythmia-patients. Design Methods: Studies I II single-centre studies referred RFA, two different diagnoses. Assessments concerning performed using questionnaires, SF-36 EQ-5D (I-II). Further, asked disease-specific questions (I). Study describes assessments before follow-up at three twelve months after RFA. Patients’ scoring was compared age gender matched reference groups III IV describe development validation questionnaire ASTA (Arrhythmia-Specific Tachycardia Arrhythmia) assessing HRQOL. multicentre studies. Patients planned DC-conversion, AF seeking emergency those forms included. Results: scored significantly lower seven SF-36’s eight scales treatment. Frequent attacks had negative impact on HRQOL, female older factors contributing worse restored patients’ Most positive effects seen follow-up. One year group similar level, assessed index (II). validated found have good psychometric properties. Construct validity confirmed sufficient levels item-total correlations scale scales. dimensionality established confirmatory factor analysis, supporting physical mental subscale. internal consistency, demonstrated Cronbach’s alpha (α), satisfactory scales, varying from α 0.79 0.91 (III-IV). Conclusions clinical implications: how impaired restore equal level that group. PROs important take into consideration arrhythmia-patients, subjective situation. To best our knowledge first forms. newly contribution assessment

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