New perspectives and strategy research biomarkers for hepatocellular carcinoma
作者： Raphaël Saffroy , Patrick Pham , Maâmar Reffas , Mohamed Takka , Antoinette Lemoine
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摘要: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Cirrhosis caused by hepatitis B virus, C virus or chronic alcohol intake associated with major risk. Systematic screening for HCC of asymptomatic patients cirrhosis needed earlier detection small tumors requiring treatment (liver transplantation, surgical resection, percutaneous techniques). The recommended strategy among cirrhotic based on regular liver ultrasonography serum alpha-fetoprotein (AFP) assay. As performance AFP not satisfactory, additional tumoral markers are proposed (des-gamma-carboxyprothrombin, glycosylated AFP-L3 fraction). Currently, diagnosis in includes non-invasive tests (imaging after contrast administration, assay); diagnostic biopsy performed when imaging limited. After treatment, tumor recurrence assessed follow-up (AFP assay and imaging). Despite lack accurate markers, recent developments genomic proteomic approaches will allow discovery new biomarkers primary tumors, as well recurrence. This review summarizes current state screening, HCC, highlights perspectives field.
sci-hub.se 参考文章(118)
F. Chiappini, Microsatellite instability mutator phenotype in hepatocellular carcinoma in non-alcoholic and non-virally infected normal livers Carcinogenesis. ,vol. 25, pp. 541- 547 ,(2003) , 10.1093/CARCIN/BGH035
Jordi Bruix, Morris Sherman, Management of hepatocellular carcinoma. Hepatology. ,vol. 42, pp. 1208- 1236 ,(2005) , 10.1002/HEP.20933
Jordi Bruix, Josep M. Llovet, Prognostic prediction and treatment strategy in hepatocellular carcinoma Hepatology. ,vol. 35, pp. 519- 524 ,(2002) , 10.1053/JHEP.2002.32089
Snorri S. Thorgeirsson, Joe W. Grisham, Molecular pathogenesis of human hepatocellular carcinoma. Nature Genetics. ,vol. 31, pp. 339- 346 ,(2002) , 10.1038/NG0802-339
Seung Kew Yoon, Nam Kyu Lim, Seon-Ah Ha, Yong Gyu Park, Jong Young Choi, Kyu Won Chung, Hee Sik Sun, Myung Ja Choi, Junho Chung, Jack R. Wands, Jin Woo Kim, The Human Cervical Cancer Oncogene Protein Is a Biomarker for Human Hepatocellular Carcinoma Cancer Research. ,vol. 64, pp. 5434- 5441 ,(2004) , 10.1158/0008-5472.CAN-03-3665
Vincenzo Mazzaferro, Enrico Regalia, Roberto Doci, Salvatore Andreola, Andrea Pulvirenti, Federico Bozzetti, Fabrizio Montalto, Mario Ammatuna, Alberto Morabito, Leandro Gennari, Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis The New England Journal of Medicine. ,vol. 334, pp. 693- 699 ,(1996) , 10.1056/NEJM199603143341104
Benoît Terris, Pascal Pineau, Laurence Bregeaud, Dominique Valla, Jacques Belghiti, Pierre Tiollais, Claude Degott, Anne Dejean, Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas Oncogene. ,vol. 18, pp. 6583- 6588 ,(1999) , 10.1038/SJ.ONC.1203051
Carrie R Graveel, Tim Jatkoe, Steven J Madore, Alison L Holt, Peggy J Farnham, Expression profiling and identification of novel genes in hepatocellular carcinomas. Oncogene. ,vol. 20, pp. 2704- 2712 ,(2001) , 10.1038/SJ.ONC.1204391
Marina Salvucci, Antoinette Lemoine, Raphaël Saffroy, Daniel Azoulay, Bénédicte Lepère, Stéphanie Gaillard, Henri Bismuth, Michel Reynès, Brigitte Debuire, Microsatellite instability in European hepatocellular carcinoma Oncogene. ,vol. 18, pp. 181- 187 ,(1999) , 10.1038/SJ.ONC.1202279
Claire-Angélique Renard, Geneviève Fourel, Marie-Pierre Bralet, Claude Degott, Alix De La Coste, Christine Perret, Pierre Tiollais, Marie Annick Buendia, Hepatocellular carcinoma in WHV/N-myc2 transgenic mice: oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles. Oncogene. ,vol. 19, pp. 2678- 2686 ,(2000) , 10.1038/SJ.ONC.1203617