Chlorhexidine decreases the risk of ventilator-associated pneumonia in intensive care unit patients: a randomized clinical trial.

摘要: Ozcaka O, Basoglu OK, Buduneli N, Tasbakan MS, Bacakoglu F, Kinane DF. Chlorhexidine decreases the risk of ventilator-associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S Background and Objective:  The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) (VAP) (ICU) patients. Material Methods:  Sixty-one dentate patients scheduled for invasive mechanical ventilation at least 48 h were included this randomized, double-blind, controlled study. As these variably incapacitated, provided by mucosa four times/d CHX group (29 patients) saline control (32 patients). Clinical periodontal measurements recorded, lower-respiratory-tract specimens obtained microbiological analysis on admission when VAP suspected. Pathogens identified quantifying colonies using standard culture techniques. Results:  Ventilator-associated developed 34/61 (55.7%) within 6.8 d. development rate significantly higher than (68.8% vs. 41.4%, respectively; p = 0.03) an odds ratio 3.12 (95% confidence interval = 1.09–8.91). Acinetobacter baumannii most common pathogen (64.7%) all species identified. There no significant differences between two groups measurements, time, pathogens detected or mortality rate. Conclusion:  finding present study, that reduces mechanically ventilated patients, strongly supports its use ICUs indeed importance adequate hygiene preventing medical complications.