Cognitive plasticity in normal and pathological aging.

摘要: The main goal of the present study is to examine what extent age and cognitive impairment contribute learning performance (cognitive plasticity, modifiability, or potential). To address this question, participants coming from four studies (Longitudinal Study Active Aging, range, 55-75 years, N = 458; Longitudinal in very old (90+), 90-102, 188, Cognitive Plasticity within Course Impairment, 97 "Normal", 57 mild (MCI), 98 Alzheimer's disease (AD) patients) were examined through a measure verbal (developed Rey). results show that all age, MCI, AD groups learned across five trials test, but significant differences found due pathology, education. effects pathology (MCI AD) can be expressed metric "years normal decline by age"; specifically, being MCI means suffering an equivalent individual during 15 whereas impact 22.7 years. Likewise, improvement associated with about 5 years education 1 year less aging. Also, two pathological significantly differed "normal" delayed trial test. most dramatic difference between group patients, which shows relatively poorer for than first trial. potential role unique effect quick detection purposes assessed (in 75-89 sensitivity specificity equal 0.813 0.917, respectively).