Inhibition of cancer cell growth by BRCA2.
作者： Mien Chie Hung , Su Zhang , Ruping Shao , Shao Chun Wang , Li Kuo Su
DOI:
关键词:
摘要: The breast cancer susceptibility gene BRCA2 has been suggested to function as a “caretaker” of the genome. Cells without wild-type are deficient in repairing DNA damage. However, whether can also suppress oncogenesis by regulating cell proliferation remains be determined. To address this question, expression protein was reconstituted, an either constitutive or regulated manner, pancreatic line Capan-1, which expresses only mutant BRCA2. Expression inhibited culture and suppressed tumor growth animals. Our results showed that, addition repair function, suppresses development inhibiting growth.
aacrjournals.org参考文章(21)
Ralph H. Hruban, Mieke Schutte, Charles J. Yeo, Henry T. Lynch, Scott E. Kern, Craig L. Weinstein, Charles E. Jackson, Michael Goggins, Gloria M. Petersen, Jia Lu, Christopher A. Moskaluk, Germline BRCA2 Gene Mutations in Patients with Apparently Sporadic Pancreatic Carcinomas Cancer Research. ,vol. 56, pp. 5360- 5364 ,(1996)
R H Hruban, C J Yeo, S E Kern, C Caldas, A B Seymour, M S Redston, L da Costa, p53 Mutations in Pancreatic Carcinoma and Evidence of Common Involvement of Homocopolymer Tracts in DNA Microdeletions Cancer Research. ,vol. 54, pp. 3025- 3033 ,(1994)
Piri L Welcsh, Kelly N Owens, Mary-Claire King, Insights into the functions of BRCA1 and BRCA2. Trends in Genetics. ,vol. 16, pp. 69- 74 ,(2000) , 10.1016/S0168-9525(99)01930-7
Lingyi Huang, Deborah Lang, Joseph Geradts, Takeshi Obara, Andres J. P. Klein-Szanto, Henry T. Lynch, Bruce A. Ruggeri, Molecular and immunochemical analyses ofRB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines Molecular Carcinogenesis. ,vol. 15, pp. 85- 95 ,(1996) , 10.1002/(SICI)1098-2744(199602)15:2<85::AID-MC1>3.0.CO;2-Q
Ketan J Patel, PCC Veronica, Hyunsook Lee, Anne Corcoran, Fiona C Thistlethwaite, Martin J Evans, William H Colledge, Lori S Friedman, Bruce AJ Ponder, Ashok R Venkitaraman, None, Involvement of Brca2 in DNA repair. Molecular Cell. ,vol. 1, pp. 347- 357 ,(1998) , 10.1016/S1097-2765(00)80035-0
Li-Kuo Su, Christopher J. Barnes, Weizhe Yao, Yi Qi, Patrick M. Lynch, Gideon Steinbach, Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. American Journal of Human Genetics. ,vol. 67, pp. 582- 590 ,(2000) , 10.1086/303058
Kenneth W. Kinzler, Bert Vogelstein, Cancer-susceptibility genes. Gatekeepers and caretakers Nature. ,vol. 386, pp. 761- 763 ,(1997) , 10.1038/386761A0
J. Yu, L. Zhang, P. M. Hwang, C. Rago, K. W. Kinzler, B. Vogelstein, Identification and classification of p53-regulated genes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 14517- 14522 ,(1999) , 10.1073/PNAS.96.25.14517
Frances Connor, David Bertwistle, P. Joseph Mee, Gillian M. Ross, Sally Swift, Elena Grigorieva, Victor L. J. Tybulewicz, Alan Ashworth, Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation Nature Genetics. ,vol. 17, pp. 423- 430 ,(1997) , 10.1038/NG1297-423
Lei Zheng, Shang Li, Thomas G Boyer, Wen-Hwa Lee, None, Lessons learned from BRCA1 and BRCA2. Oncogene. ,vol. 19, pp. 6159- 6175 ,(2000) , 10.1038/SJ.ONC.1203968