Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviors
作者： Robert J Ursano , Minna Männikkö , Carlos Morcillo-Suarez , David Laibson , Urs Fischbacher
DOI: 10.1101/261081
关键词:
摘要: Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) general risk tolerance, adventurousness, and risky behaviors the driving, drinking, smoking, sexual domains. We identified 611 approximately independent genetic loci associated with at least our phenotypes, including 124 tolerance. report evidence substantial shared influences across tolerance behaviors: 72 contain lead SNP for other GWAS, is moderately strongly genetically correlated (|rˆ g | ~ 0.25 0.50) range behaviors. Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed brain tissues point role glutamatergic GABAergic neurotransmission. find no enrichment previously hypothesized relate
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