Trypanosoma cruzi: Role of δ-Amastin on Extracellular Amastigote Cell Invasion and Differentiation

摘要: Trypanosoma cruzi is a protozoan parasite that comprises different phylogenetic groups and the causative agent of Chagas’ disease. Different T. strains present differences in infectivity vitro vivo experimental models, which are likely related to expression virulence factors. Amastin surface glycoprotein abundantly expressed on intracellular mammalian amastigote form parasite. In this study, we showed highly infective strain (G strain) extracellular (EA) invasive forms reduced RNA levels amastin compared less (CL). The treatment HeLa cells with recombinant δ-amastin EA forms. However, ectopic accelerated differentiation into trypomastigotes. Corroborating behavior association expression, EAs overexpressing were precociously robustly observed liver susceptible mouse (A/JUnib), whereas parasitemia was never detected assays. This first report regulatory role course both infection.