Cell cycle and cell death in disease: past, present and future

摘要: Cell division and cell death are the two predominant physiological processes that regulate tissue homeostasis in adult organism. The importance of dysregulation these pathogenesis major diseases, such as cancer, myocardial infarction, stroke, atherosclerosis, infection, inflammation neurodegenerative disorders, is becoming increasingly evident. Hence, attempts to find modulators cycle programmes being made with hope creating novel therapeutic approaches treatment diseases. It clear improved understanding how cells balance life-and-death crucial for this development. In view this, a Nobel Symposium entitled 'The Cycle Apoptosis Disease' was organized conjunction celebration 200-year anniversary Karolinska Institute 2010. symposium focused on cycle/cell human disease. Three comprehensive reviews based presentations at presented issue Journal Internal Medicine. They include discussion autophagy anticancer therapy, description role type 2 transglutaminase Huntington's disease proposal 'redox-sensing' mechanisms might act an orthogonal control apoptosis signalling.