PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population
作者： Shizhi Wang , Shenshen Wu , Haixia Zhu , Bo Ding , Yunlang Cai
DOI: 10.1038/SREP23465
关键词:
摘要: Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given is reported be overexpressed cervical cancer can influence transcription, we aimed determine of cancer. The genotyping was performed 1126 cases 1237 controls. Our results showed TT genotype significantly a reduced risk (adjusted OR = 0.55, 95% CI = 0.38–0.79; recessive model). Stratified analyses revealed that restricted subgroups age > 49 years, parity ≤ 1, abortion early-stage Immunohistochemistry assay individuals carrying having lower expression than those CC/CT genotypes. In summary, may serve as biomarker particularly
nature.com
harvard.edu
sci-hub.se 参考文章(26)
Hiroe Ono, Nobuyoshi Hiraoka, Yeon-Su Lee, Sang Myung Woo, Woo Jin Lee, Il Ju Choi, Akira Saito, Kazuyoshi Yanagihara, Yae Kanai, Sumiko Ohnami, Fumiko Chiwaki, Hiroki Sasaki, Hiromi Sakamoto, Teruhiko Yoshida, Norihisa Saeki, Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes, Chromosomes and Cancer. ,vol. 51, pp. 30- 41 ,(2012) , 10.1002/GCC.20928
Y.-P. Fu, I. Kohaar, N. Rothman, J. Earl, J. D. Figueroa, Y. Ye, N. Malats, W. Tang, L. Liu, M. Garcia-Closas, B. Muchmore, N. Chatterjee, M. Tarway, M. Kogevinas, P. Porter-Gill, D. Baris, A. Mumy, D. Albanes, M. P. Purdue, A. Hutchinson, A. Carrato, A. Tardon, C. Serra, R. Garcia-Closas, J. Lloreta, A. Johnson, M. Schwenn, M. R. Karagas, A. Schned, W. R. Diver, S. M. Gapstur, M. J. Thun, J. Virtamo, S. J. Chanock, J. F. Fraumeni, D. T. Silverman, X. Wu, F. X. Real, L. Prokunina-Olsson, Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 4974- 4979 ,(2012) , 10.1073/PNAS.1202189109
Chihua Wen, China's plans to curb cervical cancer. Lancet Oncology. ,vol. 6, pp. 139- 141 ,(2005) , 10.1016/S1470-2045(05)01761-4
Keitaro Matsuo, Kazuo Tajima, Takeshi Suzuki, Takakazu Kawase, Miki Watanabe, Kohei Shitara, Kazunari Misawa, Seiji Ito, Akira Sawaki, Kei Muro, Tsuneya Nakamura, Kenji Yamao, Yoshitaka Yamamura, Nobuyuki Hamajima, Akio Hiraki, Hideo Tanaka, Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese. International Journal of Cancer. ,vol. 125, pp. 1961- 1964 ,(2009) , 10.1002/IJC.24519
Teri A Manolio, Cohort studies and the genetics of complex disease Nature Genetics. ,vol. 41, pp. 5- 6 ,(2009) , 10.1038/NG0109-5
Gregor Bahrenberg, Andreas Brauers, Hans-Georg Joost, Gerhard Jakse, Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors. Biochemical and Biophysical Research Communications. ,vol. 275, pp. 783- 788 ,(2000) , 10.1006/BBRC.2000.3393
Paul Lochhead, Bernd Frank, Georgina L Hold, Charles S Rabkin, Michael TH Ng, Thomas L Vaughan, Harvey A Risch, Marilie D Gammon, Jolanta Lissowska, Melanie N Weck, Elke Raum, Heiko Müller, Thomas Illig, Norman Klopp, Alan Dawson, Kenneth E McColl, Hermann Brenner, Wong–Ho Chow, Emad M El–Omar, None, Genetic Variation in the Prostate Stem Cell Antigen Gene and Upper Gastrointestinal Cancer in White Individuals Gastroenterology. ,vol. 140, pp. 435- 441 ,(2011) , 10.1053/J.GASTRO.2010.11.001
Chizu Tanikawa, Yuji Urabe, Keitaro Matsuo, Michiaki Kubo, Atsushi Takahashi, Hidemi Ito, Kazuo Tajima, Naoyuki Kamatani, Yusuke Nakamura, Koichi Matsuda, A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population Nature Genetics. ,vol. 44, pp. 430- 434 ,(2012) , 10.1038/NG.1109
, Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nature Genetics. ,vol. 40, pp. 730- 740 ,(2008) , 10.1038/NG.152
Emanuele Marra, Paolo Uva, Valentina Viti, Valeria Simonelli, Eugenia Dogliotti, Emanuele De Rinaldis, Armin Lahm, Nicola La Monica, Alfredo Nicosia, Gennaro Ciliberto, Fabio Palombo, Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways BMC Cancer. ,vol. 10, pp. 129- 129 ,(2010) , 10.1186/1471-2407-10-129