Metabolic and genetic markers' associations with elevated levels of alanine aminotransferase in adolescents.

摘要: BACKGROUND Non-alcoholic fatty liver disease (NAFLD), the most common chronic in adolescents, is a feature of metabolic syndrome (MetS). Obesity and insulin resistance (IR) are risk factors for NAFLD, as well inflammation-related genetic markers. The relationship between or markers alanine aminotransferase (ALT) not fully understood. We examined MetS, with elevated ALT adolescents. METHODS A total 674 adolescents participated cross-sectional study Guadalajara, Mexico. Elevated (>40 IU/L), surrogate marker MetS (International Diabetes Federation definition) were evaluated. Obesity, IR, lipids, C-reactive protein (CRP) (TNFA-308G>A, CRP+1444C>T, IL1RN IL6-597/-572/-174 haplotype) Multivariate logistic regression was performed. RESULTS observed 3% 14.1% (total obese, respectively) (odds ratio [OR], 5.86; 95% confidence interval [95% CI], 1.16-25.89), (OR, 8.51; CI, 2.61-27.71), IR 9.10; 2.82-29.38), cholesterol (TC) 3.67; 1.25-10.72), low-density lipoprotein-cholesterol (LDL-C) 3.06; 1.06-8.33), non-high-density (HDL-C) 3.88; 1.27-11.90) 4.64; 1.10-19.53) associated ALT. Among males, ≥2 criteria 4.22; 1.14-15.71). CONCLUSIONS insulin, high TC, LDL-C, non-HDL-C polymorphism There an urgent need to reduce obesity prevent NAFLD.