(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.

作者: George A. Ricaurte , Jie Yuan , Una D. McCann

DOI: 10.1159/000026664

关键词:

摘要: The popular recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA; ‘Ecstasy’) is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be dem

参考文章(45)
WILLARD R. CHAPPELL, JOYCE MORDENTI, Extrapolation of Toxicological and Pharmacological Data from Animals to Humans Advances in drug research. ,vol. 20, pp. 1- 116 ,(1991) , 10.1016/B978-0-12-013320-8.50005-8
N. Aguirre, B. Lasheras, J. Del Rio, M. Barrionuevo, The Role of Dopaminergic Systems in the Perinatal Sensitivity to 3,4-Methylenedioxymethamphetamine-Induced Neurotoxicity in Rats Journal of Pharmacology and Experimental Therapeutics. ,vol. 286, pp. 1159- 1165 ,(1998)
E B De Souza, G Battaglia, S Marra, J N Johannessen, T R Insel, 3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics. ,vol. 249, pp. 713- 720 ,(1989)
G A Ricaurte, J L Katz, A L Martello, M B Martello, Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations. Journal of Pharmacology and Experimental Therapeutics. ,vol. 261, pp. 616- 622 ,(1992)
C J Schmidt, Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Journal of Pharmacology and Experimental Therapeutics. ,vol. 240, pp. 1- 7 ,(1987)
K.T. Finnegan, G.A. Ricaurte, L.D. Ritchie, I. Irwin, S.J. Peroutka, J.W. Langston, Orally administered MDMA causes a long-term depletion of serotonin in rat brain. Brain Research. ,vol. 447, pp. 141- 144 ,(1988) , 10.1016/0006-8993(88)90974-2