In vitro models of spinal motor circuit's development in mammals: achievements and challenges.

作者: Alfonso Martinez-Arias , Stéphane Nedelec , Stéphane Nedelec

DOI: 10.1016/J.CONB.2020.12.002

关键词:

摘要: The connectivity patterns of neurons sustaining the functionality spinal locomotor circuits rely on specification hundreds motor neuron and interneuron subtypes precisely arrayed within embryonic cord. Knowledge acquired by developmental biologists molecular mechanisms underpinning this process in vivo has supported development 2D 3D differentiation strategies to generate neuronal diversity from mouse human pluripotent stem cells (PSCs). Here, we review recent breakthroughs field perspectives opened up models vitro embryogenesis approach underlying diversification formation functional circuits. Beyond serving fundamental investigations, these new approaches should help engineering differentially impacted neuromuscular disorders, such as amyotrophic lateral sclerosis or muscular atrophies, thus open avenues for disease modeling drug screenings.

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