Development and in vitro evaluation of novel buccoadhesive tablet formulation of prednisolone

摘要: Buccoadhesive tablets for the treatment of aphtha were prepared by mixing prednisolone with various amounts different polymers. The adhesion each formulation was measured as well release drug from buccoadhesive tablets. increasing concentrations Polycarbophil (PCP) and Carbopol 934p (CP) caused higher adhesive properties formulations. However, force did not change upon concentration sodium carboxymethyl cellulose (CMC) in Increasing hydroxypropylmethyl (SCMC) formulations containing CP PCP a downward shift viscosities. viscosity fabricated CMC affected HPMC concentration. combination 5% CP, 10% demonstrated pronounced significant sigmoidal after logical lag time.