摘要: Despite metformin being one of the most commonly prescribed drugs for treatment diabetes, how it elicits its therapeutic effects has remained mysterious. A new study in mice shows that inhibitory phosphorylation acetyl-coA carboxylases Acc1 and Acc2 by AMP-activated protein kinase (AMPK) is essential ability to improve insulin sensitivity lower blood glucose obesity (pages 1649–1654).
nature.com
readcube.com 参考文章(16)
Mark R. OWEN, Elena DORAN, Andrew P. HALESTRAP, Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochemical Journal. ,vol. 348, pp. 607- 614 ,(2000) , 10.1042/BJ3480607
B. Viollet, B. Guigas, J. Leclerc, S. Hébrard, L. Lantier, R. Mounier, F. Andreelli, M. Foretz, AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives Acta Physiologica. ,vol. 196, pp. 81- 98 ,(2009) , 10.1111/J.1748-1716.2009.01970.X
D. Grahame Hardie, Fiona A. Ross, Simon A. Hawley, AMPK: a nutrient and energy sensor that maintains energy homeostasis Nature Reviews Molecular Cell Biology. ,vol. 13, pp. 251- 262 ,(2012) , 10.1038/NRM3311
Russell A. Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J. Birnbaum, Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP Nature. ,vol. 494, pp. 256- 260 ,(2013) , 10.1038/NATURE11808
Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason R B Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg, Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nature Medicine. ,vol. 19, pp. 1649- 1654 ,(2013) , 10.1038/NM.3372
Mohamad-Yehia El-Mir, Véronique Nogueira, Eric Fontaine, Nicole Avéret, Michel Rigoulet, Xavier Leverve, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. Journal of Biological Chemistry. ,vol. 275, pp. 223- 228 ,(2000) , 10.1074/JBC.275.1.223
Jian Yang, Shanna Maika, Lauren Craddock, Judy A. King, Zhi-Mei Liu, Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice. Biochemical and Biophysical Research Communications. ,vol. 370, pp. 248- 253 ,(2008) , 10.1016/J.BBRC.2008.03.094
Maria M. Mihaylova, Reuben J. Shaw, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism Nature Cell Biology. ,vol. 13, pp. 1016- 1023 ,(2011) , 10.1038/NCB2329
Barbara Cool, Bradley Zinker, William Chiou, Lemma Kifle, Ning Cao, Matthew Perham, Robert Dickinson, Andrew Adler, Gerard Gagne, Rajesh Iyengar, Gang Zhao, Kennan Marsh, Philip Kym, Paul Jung, Heidi S. Camp, Ernst Frevert, Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metabolism. ,vol. 3, pp. 403- 416 ,(2006) , 10.1016/J.CMET.2006.05.005
François R. Jornayvaz, Gerald I. Shulman, Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metabolism. ,vol. 15, pp. 574- 584 ,(2012) , 10.1016/J.CMET.2012.03.005