The rhodopsin content of human eyes.
作者： Anne B. Fulton , Janice Dodge , Ronald M. Hansen , Theodore P. Williams
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摘要: PURPOSE. To measure the total amount of rhodopsin in human eyes across life span and to test hypothesis that content infants' elderly's is lower than at other ages. METHODS. Rhodopsin was extracted from retinal pigment epithelial fractions 196 102 donors, ages 27 weeks' gestation through 94 years, using quantitative procedures. recover photopigment bleached by unavoidable light exposure, 78 were incubated with 9-cis retinal. The (retinal plus fractions) per eye examined for significant changes age, higher value pairs eyes. RESULTS. median adults 6.45 nmoles (range, 3.33-10.84 nmoles) 8 or more recovered 28% all adult (<12 months postterm) significantly older individuals increases age. After infancy, no change age found. For both infants adults, without reducing variance recovered. estimated be 50% early approximately 5 weeks postterm (95% confidence interval, 0-10 postterm). CONCLUSIONS. A developmental increase occurs during infancy. Thereafter remains constant. quite variable. Bleaching alone cannot explain variability.
arvojournals.org参考文章(25)
E Pulos, Changes in rod sensitivity through adulthood. Investigative Ophthalmology & Visual Science. ,vol. 30, pp. 1738- 1742 ,(1989)
Anne B. Fulton, Ronald M. Hansen, Janice Dodge, Theodore P. Williams, Photoreceptor Development and Photostasis Springer, Boston, MA. pp. 189- 198 ,(1998) , 10.1007/978-1-4899-1549-8_11
E. N. Pugh, B. Falsini, A. L. Lyubarsky, The Origin of the Major Rod- and Cone-Driven Components of the Rodent Electroretinogram and the Effect of Age and Light-Rearing History on the Magnitude of These Components Springer US. pp. 93- 128 ,(1998) , 10.1007/978-1-4899-1549-8_7
A B Fulton, R M Hansen, O Findl, The development of the rod photoresponse from dark-adapted rats. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 1038- 1045 ,(1995)
Anne B. Fulton, Janice Dodge, Ronald M. Hansen, Theodore P. Williams, Charles Parker, Rhodopsin in immature rod outer segments. Investigative Ophthalmology & Visual Science. ,vol. 37, pp. 1951- 1956 ,(1996)
F. J.G.M. Van Kuijk, J. W. Lewis, P. Buck, D. S. Kliger, K. R. Parker, Spectrophotometric quantitation of rhodopsin in the human retina. Investigative Ophthalmology & Visual Science. ,vol. 32, pp. 1962- 1967 ,(1991)
H Gao, J G Hollyfield, Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. ,vol. 33, pp. 1- 17 ,(1992)
Sven Erik Nilsson, Gunnar Hoglund, Joachim Schwemer, Visual pigment and visual receptor cells in fetal and adult sheep. Investigative Ophthalmology & Visual Science. ,vol. 23, pp. 409- 418 ,(1982)
X Reynaud, A B Fulton, R M Hansen, T P Williams, C A Lemere, C Parker, Rod photoreceptors in infant rats with a history of oxygen exposure. Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 168- 174 ,(1999)
C L Millican, C A Curcio, K A Allen, R E Kalina, Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 3278- 3296 ,(1993)