Obesity and risk of sepsis: a population-based cohort study.

摘要: Objective Sepsis, the syndrome of microbial infection complicated by systemic inflammation, is associated with significant morbidity and mortality. To determine if obesity increases risk sepsis events. Design Methods Data from 30,239 subject population-based longitudinal cohort study REasons for Geographic Racial Differences in Stroke (REGARDS) were used. Using measurements at start study, we defined using body mass index (BMI; 102 cm or female >88 cm] = obese). Over an 8-year observation period, evaluated association between subsequent events, adjusting sociodemographic factors, health behaviors, chronic medical conditions, statin use, high-sensitivity C-reactive protein. Results There 975 incident events. Compared to those a BMI 18.5-24.9, was higher only ≥ 40 (hazard ratio [HR] 1.57, [1.16-2.14]). Risk increased WC (HR 1.34 [1.14-1.56]). In model both WC, 1.47 [1.20-1.79]) but not BMI. Conclusions Obesity independently future better predictor than BMI.