The Multiple Roles of the IAP Super-family in cancer.
作者： Swati Kumar , Ciaran Fairmichael , Daniel B. Longley , Richard C. Turkington
DOI: 10.1016/J.PHARMTHERA.2020.107610
关键词:
摘要: The Inhibitor of Apoptosis proteins (IAPs) are a family that mainly known for their anti-apoptotic activity and ability to directly bind inhibit caspases. Recent research has however revealed they have extensive roles in governing numerous other cellular processes. IAPs modulate ubiquitin (Ub)-dependent signaling pathways through E3 ligase influence activation nuclear factor κB (NF-κB). In this review, we discuss the involvement individual hallmarks cancer current status therapies targeting these critical proteins.
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