Janus Faces of Amyloid Proteins in Neuroinflammation

摘要: Amyloid forming molecules are generally considered harmful. In Alzheimer's Disease two amyloid Aβ A4 and tau vie for consideration as the main pathogenic culprit. But obey laws of chemistry defy way we categorize them humans with our well-known proclivities to bias in reasoning. We have been exploring brains multiple sclerosis patients identify that associated protection from inflammation degeneration. 2001 noted aB crystallin (cryab) was most abundant transcript found MS lesions, but not healthy brains. Cryab can reverse paralysis attenuate several models including experimental autoimmune encephalomyelitis (EAE), various ischemia. is an molecule. identified a core structure common many amyloids protein A4, tau, amylin, prion protein, serum P, cryab. The hexapeptide highly immune suppressive EAE when administered systemically. Administration this quickly lowers inflammatory cytokines plasma like IL-6 IL-2. bind set proinflammatory mediators plasma, acute phase reactants complement components. beneficial properties hexapeptides provide potential new therapeutic direction. These experiments indicate Janus faces, providing unexpected benefit neuroinflammatory conditions.