Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial Infarction by Upregulating SDF-1/CXCR4: A Pilot Study
作者： Lu Li , Shengzheng Wu , Zheng Liu , Zhongxiong Zhuo , Kaibin Tan
DOI: 10.1155/2015/691310
关键词:
摘要: Mesenchymal stem cell (MSC) therapy shows considerable promise for the treatment of myocardial infarction (MI). However, inefficient migration and homing MSCs after systemic infusion have limited their therapeutic applications. Ultrasound-targeted microbubble destruction (UTMD) has proven to be promising improve ischemic myocardium, but concrete mechanism remains unclear. We hypothesize that UTMD promotes MSC by upregulating SDF-1/CXCR4, this study was aimed at exploring potential mechanism. analyzed SDF-1/CXCR4 expression in vitro vivo counted number MI areas. The results demonstrated not only led elevated secretion SDF-1 also resulted an increased proportion expressed surface CXCR4. findings show increase higher combined with group compared other groups. In conclusion, can myocardium upregulate CXCR4 on MSCs, which provides a molecular assisted via axis.
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