Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research.
作者： Lasse Nyholm , Adam Koziol , Sofia Marcos , Amanda Bolt Botnen , Ostaizka Aizpurua
DOI: 10.1016/J.ISCI.2020.101414
关键词:
摘要: From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by bidirectional interactions between host and their associated microbiota. Current technology can reveal many such combining multi-omic data from both hosts microbes. However, exploring full extent these requires careful consideration study design for efficient generation optimal integration derived (meta)genomics, (meta)transcriptomics, (meta)proteomics, (meta)metabolomics. In this perspective, we introduce holo-omic approach that incorporates microbiota domains untangle interplay two. We revisit recent literature on biomolecular host-microbe discuss implementation current limitations approach. anticipate application contribute opening new research avenues discoveries in biomedicine, biotechnology, agricultural aquacultural sciences, nature conservation, as well basic ecological evolutionary research.
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