Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling.

摘要: The AKT family of serine threonine kinases is critical importance with regard to growth factor signaling, cell proliferation, survival and oncogenesis. Engagement signaling receptors induces the lipid kinase, phosphatidylinositol 3-kinase (PI3K), which enables activation AKT. Responsive PI3K/AKT pathway mammalian target rapamycin (mTOR), a major effector that specifically implicated in regulation as result nutrient availability cellular bioenergetics. These mediate activity multitude intracellular molecules intersect multiple pathways regulate processes. Elucidating role AKT/mTOR metabolism hallmark are aberrantly affected cancer has provided solid foundation discoveries. From this, new research directions emerging diabetes T cell-mediated immunity. As result, perspective developing how functions within maintain homeostasis. An appreciation altered equilibrium contributes disease malignancy. Such insights may lead novel intervention strategies be useful reprogram or reset balance signaling.