Potential of Molecular Biology in Preoperative Evaluation

作者: Philip Quirke , Lynn Cawkwell

DOI: 10.1007/978-3-642-60514-7_7

关键词:

摘要: Molecular biological knowledge will only be used if it can replace or complement current knowledge. It must able to do this more rapidly and ideally at lower cost than methods. A large number of studies mature in the next 3–5 years make claims for value using a particular method clinical practice. Prior adopting them usage, they should carefully evaluated, since is relatively easier publish positive series negative series. when several retrospective preferably prospective have been performed compared against gold standards prognosis derived from histopathological staging grading rectal cancer that newer techniques adopted.

参考文章(65)
SM Bell, SA Kelly, JA Hoyle, FA Lewis, GR Taylor, H Thompson, MF Dixon, P Quirke, c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis. British Journal of Cancer. ,vol. 64, pp. 174- 178 ,(1991) , 10.1038/BJC.1991.264
Seamus J. Martin, Douglas R. Green, Apoptosis and cancer: the failure of controls on cell death and cell survival☆ Critical Reviews in Oncology Hematology. ,vol. 18, pp. 137- 153 ,(1995) , 10.1016/1040-8428(94)00124-C
Lauri A Aaltonen, Päivi Peltomäki, Fredrick S Leach, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Steven M Powell, Jin Jen, Stanley R Hamilton, Gloria M Petersen, Kenneth W Kinzler, Bert Vogelstein, Albert De La Chapelle, Clues to the pathogenesis of familial colorectal cancer Science. ,vol. 260, pp. 812- 816 ,(1993) , 10.1126/SCIENCE.8484121
C. Eric Bronner, Sean M. Baker, Paul T. Morrison, Gwynedd Warren, Leslie G. Smith, Mary Kay Lescoe, Michael Kane, Christine Earabino, James Lipford, Annika Lindblom, Pia Tannergård, Roni J. Bollag, Alan R. Godwin, David C. Ward, Magnus Nordenskj⊘ld, Richard Fishel, Richard Kolodner, R. Michael Liskay, Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer Nature. ,vol. 368, pp. 258- 261 ,(1994) , 10.1038/368258A0
Lynn Cawkwell, Ding Li, Fraser A. Lewis, Iain Martin, Michael F. Dixon, Philip Quirke, Microsatellite instability in colorectal cancer: Improved assessment using fluorescent polymerase chain reaction Gastroenterology. ,vol. 109, pp. 465- 471 ,(1995) , 10.1016/0016-5085(95)90334-8
David Hockenbery, Gabriel Nuñez, Curt Milliman, Robert D. Schreiber, Stanley J. Korsmeyer, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death Nature. ,vol. 348, pp. 334- 336 ,(1990) , 10.1038/348334A0
ANTONETIE C Preisinger, PHILIP Hedge, DOUGLAS McKechnie, R Finniear, A Markham, J Groffen, M Boguski, S Altschui, A Horii, H Ando, Y Miyoshi, Y Miki, I Nishisho, Y Nakamura, Identification of FAP locus genes from chromosome 5q21 Science. ,vol. 253, pp. 661- 665 ,(1991) , 10.1126/SCIENCE.1651562
K.K. Tanabe, L.M. Ellis, H. Saya, Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. The Lancet. ,vol. 341, pp. 725- 726 ,(1993) , 10.1016/0140-6736(93)90490-8
J. Drummond, G. Li, M. Longley, P Modrich, Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science. ,vol. 268, pp. 1909- 1912 ,(1995) , 10.1126/SCIENCE.7604264
Walter Bodmer, Tim Bishop, Peter Karran, Genetic steps in colorectal cancer Nature Genetics. ,vol. 6, pp. 217- 219 ,(1994) , 10.1038/NG0394-217