Simulation Studies of A Phenomenological Model for the Assembly of Elongated Virus Capsids
作者： Sharon C. Glotzer , Ting Chen
DOI:
关键词:
摘要: We extend our previously developed general approach (1) to study a phenomenological model in which the simulated packing of hard, attractive spheres on prolate spheroid surface with convexity constraints produces structures identical those virus capsid structures. Our simulation combines traditional Monte Carlo method random sampling an ellipsoidal and convex hull searching algorithm. Using this we assembly structural origin non-icosahedral, elongated capsids, such as two aberrant flock house (FHV) particles prohead bacteriophage phi29, discuss implication results context recent experimental findings.
harvard.edu
arxiv.org参考文章(24)
R. Hull, M.W. Rees, Margaret N. Short, Studies on alfalfa mosaic virus Virology. ,vol. 37, pp. 404- 415 ,(1969) , 10.1016/0042-6822(69)90224-4
Adam Zlotnick, To Build a Virus Capsid: An Equilibrium Model of the Self Assembly of Polyhedral Protein Complexes Journal of Molecular Biology. ,vol. 241, pp. 59- 67 ,(1994) , 10.1006/JMBI.1994.1473
R. Zandi, D. Reguera, R. F. Bruinsma, W. M. Gelbart, J. Rudnick, Origin of icosahedral symmetry in viruses Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 15556- 15560 ,(2004) , 10.1073/PNAS.0405844101
Michael F Moody, Geometry of phage head construction. Journal of Molecular Biology. ,vol. 293, pp. 401- 433 ,(1999) , 10.1006/JMBI.1999.3011
William R. Wikoff, John E. Johnson, Virus assembly: Imaging a molecular machine Current Biology. ,vol. 9, ,(1999) , 10.1016/S0960-9822(99)80183-3
I. L. Ivanovska, P. J. de Pablo, B. Ibarra, G. Sgalari, F. C. MacKintosh, J. L. Carrascosa, C. F. Schmidt, G. J. L. Wuite, Bacteriophage capsids: tough nanoshells with complex elastic properties. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 7600- 7605 ,(2004) , 10.1073/PNAS.0308198101
R. Twarock, A tiling approach to virus capsid assembly explaining a structural puzzle in virology Journal of Theoretical Biology. ,vol. 226, pp. 477- 482 ,(2004) , 10.1016/J.JTBI.2003.10.006
E. Bannai, N. J. A. Sloane, J. H. Conway, Sphere packings, lattices, and groups ,(1987)
Alexander McPherson, Micelle formation and crystallization as paradigms for virus assembly BioEssays. ,vol. 27, pp. 447- 458 ,(2005) , 10.1002/BIES.20196
Andrei Fokine, Paul R Chipman, Petr G Leiman, Vadim V Mesyanzhinov, Venigalla B Rao, Michael G Rossmann, None, Molecular architecture of the prolate head of bacteriophage T4 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 6003- 6008 ,(2004) , 10.1073/PNAS.0400444101