Reproduction and Development

摘要: Publisher Summary This chapter reveals that developmental and reproductive toxicology are comparatively young areas of research. Before the thalidomide disaster, no routine toxicological evaluation chemically induced adverse effects on reproduction development was performed. Although malformations were experimentally using a selection substances, this not done in frame safety evaluations new medicinal products. Therefore, had been tested for possible teratogenic before marketing. The disastrous experience with has drastically altered general opinions drug risk assessment, as well legislation, all fields toxicology. systematic preclinical studies an integral part requirements needed registration pharmaceutical products certain types environmentally occurring chemicals, such pesticides.