New Views of Ovarian Carcinoma Types: How Will This Change Practice?

摘要: Ovarian carcinomas are heterogeneous, comprised of five different cell types: high-grade serous, low-grade endometrioid, clear cell, and mucinous carcinoma. High-grade serous carcinoma causes the vast majority ovarian cancer deaths. This classification correlates with a variety distinctive clinical, epidemiological, molecular, behavioral features. type-specific approach is valuable framework for understanding biology investigating novel treatment approaches. An alternative, complementary provided by dualistic model which divides into type I II tumors. Type arise from well-characterized precursor lesions (endometriosis atypical proliferative (borderline) tumors), present in low stage, have an indolent behavior (endometrioid, mucinous, carcinomas, most carcinomas). tumors advanced stage appear to progress rapidly (high-grade A body literature now converging on consensus that intraepithelial fallopian tube. These data form basis our new conceptual “ovarian cancer” ultimately hoped improve lead effective screening prevention strategies.