Age-related Alteration in the Composition of Immunocompetent Blood Cells in Atomic Bomb Survivors
作者： Yoichiro Kusunoki , Mitoshi Akiyama , Seishi Kyoizumi , Eda T. Bloom , Takashi Makinodan
DOI: 10.1080/09553008814550541
关键词:
摘要: A total of 1328 atomic bomb survivors in Hiroshima were studied to determine alterations the number blood lymphocytes belonging T-cell subpopulations, CD19 antigen-positive B cells and Leu 7 CD16 lymphocytes. Overall, with increasing age, significant decreasing trends numbers some subpopulations observed. Furthermore, positive for CD5 antigen was significantly lower people exposed radiation (greater than 1 Gy) older age group (more 30 years old at time bombing). similar tendency decreases CD4, CD8, observed these survivors, although differences not statistically significant. These results suggest that aging related immune system is accelerated irradiated advanced age. This may be explained by age-related decrease thymic function those subjects who bombing resulting a decreased functional ability after injury. On contrary, or found increased compared younger group, there little dependence on dose.
informahealthcare.com参考文章(15)
Charles M Balch, T. Abo, A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). Journal of Immunology. ,vol. 127, pp. 1024- 1029 ,(1981)
G. F. Babcock, L. L. Lanier, N. L. Warner, An My Le, J. H. Phillips, Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. Journal of Immunology. ,vol. 131, pp. 1789- 1796 ,(1983)
CAROLINE B. HALL, WILLIAM J. HALL, FRANTZ W. ASHLEY, HOWARD B. HAMILTON, SERUM IMMUNOGLOBULIN LEVELS IN ATOMIC BOMB SURVIVORS IN HIROSHIMA, JAPAN American Journal of Epidemiology. ,vol. 98, pp. 423- 429 ,(1973) , 10.1093/OXFORDJOURNALS.AJE.A121571
Mitoshi Akiyama, Michio Yamakido, Kyoko Kobuke, Donald S. Dock, Howard B. Hamilton, Akio A. Awa, Hiroo Kato, Peripheral Lymphocyte Response to PHA and T Cell Population among Atomic Bomb Survivors Radiation Research. ,vol. 93, pp. 572- 580 ,(1983) , 10.2307/3576036
Katsuiku Hirokawa, Toshihiko Sado, Radiation effects on regeneration and T-cell-inducing function of the thymus Cellular Immunology. ,vol. 84, pp. 372- 379 ,(1984) , 10.1016/0008-8749(84)90109-6
R. Langlois, W. Bigbee, S Kyoizumi, N Nakamura, M. Bean, M Akiyama, R. Jensen, Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors Science. ,vol. 236, pp. 445- 448 ,(1987) , 10.1126/SCIENCE.3563520
Hiroo Kato, William J. Schull, Akio Awa, Mitoshi Akiyama, Masanori Otake, Dose-response analyses among atomic bomb survivors exposed to low-level radiation. Health Physics. ,vol. 52, pp. 645- 652 ,(1987) , 10.1097/00004032-198705000-00017
Eda T. Bloom, Edward L. Korn, Dean S. Toji, Takashi Makinodan, Natural Cell-mediated Cytotoxicity among A-bomb Survivors Residing in the United States International Journal of Radiation Biology. ,vol. 44, pp. 213- 218 ,(1983) , 10.1080/09553008314551011
Masayuki Hakoda, Mitoshi Akiyama, Seishi Kyoizumi, Kyoko Kobuke, Akio A. Awa, Michio Yamakido, Measurement of in vivo HGPRT-deficient mutant cell frequency using a modified method for cloning human peripheral blood T-lymphocytes. Mutation Research. ,vol. 197, pp. 161- 169 ,(1988) , 10.1016/0027-5107(88)90153-4
Dale L. Preston, Donald A. Pierce, The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors. Radiation Research. ,vol. 114, pp. 437- 466 ,(1988) , 10.2307/3577117