Catecholaminergic axonal varicosities appear to innervate growth hormone-releasing hormone-immunoreactive neurons in the human hypothalamus: the possible morphological substrate of the stress-suppressed growth.
作者： Giorgio Rotoli , George Grignol , Walter Hu , Istvan Merchenthaler , Bertalan Dudas
DOI: 10.1210/JC.2011-1069
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摘要: Context: Stress is considered to be a major factor in the regulation of growth. Psychosocial dwarfism, characterized with short stature, delayed puberty, and depression, typically preceded by psychological harassment or stressful environment. It has been observed that stress suppresses GH secretion, possibly via attenuation GHRH secretion. However, exact mechanism impact on growth not elucidated yet. Objective: Our previous studies revealed intimate associations between neuropeptide Y (NPY)-immunoreactive (IR) axonal varicosities GHRH-IR perikarya human hypothalamus. Because NPY molecule, NPY-GHRH juxtapositions may represent an important stress-suppressed release. In addition NPY, catecholamines are among markers stress. Thus, present study, we examined putative catecholaminergic tyrosine hydroxylase (TH)-/dopamine-β-hydroxylase-/phenylethanolamine N-methylt...
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