摘要: Nuclear factor kappa B (NF-κB) transcription factors regulate gene expression directing inflammation and cellular survival. NF-κB complexes are homo- or heterodimers assembled from five structurally related proteins (RelA, RelB, c-Rel, p50, p52). is retained in the cytoplasm by physical interaction with inhibitor (IκB) proteins. Many cell stresses, including microbial stimuli proinflammatory cytokines, activate signaling pathways that cause IκB to be removed degraded. then accumulates nucleus, binds κB sequences DNA, recruits other nuclear chromatin, regulates of nearby genes, those for chemokines, anti-apoptotic proteins, immune effector transcriptional regulatory activated lung cells leukocytes patients respiratory diseases, suggesting activities may contribute their pathophysiology. In experimental settings, critical pulmonary inflammation, infection, acute injury, asthma, cancer. function an essential determinant health homeostasis.
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