Dietary non-digestible carbohydrates and the resistance to intestinal infections

摘要: Keywords: Non-digestible carbohydrates, prebiotics, inulin, FOS, calcium, microflora, short-chain fatty acids, mucin, intestinal permeability, salmonella, infection, rat, humanDietary non-digestible carbohydrates and the resistance to infectionsNon-digestible (NDC) stimulate protective gut microflora resulting in increased production of organic acids. This may result luminal killing acid-sensitive pathogens hence reduce colonisation translocation a pathogen. However, host defence against invasive like salmonella also depends on barrier function mucosa. High concentrations acids induce injury mucosa impair function. The aim this thesis was determine effects NDC's rats humans.In rats, well fermentable NDC (resistant starch, fructo-oligosaccharides lactulose) stimulated endogenous subsequently faecal lactate lowered pH. contrast cellulose, wheat fiber resistant rapid (FOS) lactulose drastically mucosal subsequent inflammation. Before they cytotoxicity mucus secretion. likely indicates that fermentation-induced irritating components can barrier. Indeed, permeability. Dietary calcium phosphate counteracted most adverse NDC. In humans, FOS concentrations. Moreover, secretion, indicating irritation. consumption did not significantly affect permeability.Stimulating by fermentation is often assumed be beneficial for health infections. work presented does support concept.