Abstract B13: Differential expressions of stress proteins and miRNAs in circulating exosomes in prostate cancer health disparities

摘要: African American men are about 1.5 times more likely to develop prostate cancer and 2.5 die from cancer. However, there9s no known cause of increased rate morbidity mortality in these population. Stress is well factor for the causation health disparities. a inducer post-transcriptional modification cellular levels. Survivin, member inhibitor apoptosis family can get alternatively spliced both transcriptionally post-transcriptionally. We have shown that survivin its splice variants secreted cells via exosomes, small membrane-bound vesicles used cell-cell cell-extracellular communication (1,2). MicroRNAs (miRNA) RNA, play regulatory role tumor development prognosis. Main objective present study find out differential expression patterns stress proteins miRNA circulating exosomes deived (PCa-AA) Caucasian (PCa-CC) patient populations. This novel way establishing non-invasive early detection intervention be tailored Americans different ethnicities. In this study, collected sera PCa-AA PCa-CC using commercially available ExoQuick kit. miRNAs extracted QIAGEN Differential expressions IAPs, wild type noted AA-prostate patients9 compared CC-prostate sera. Differentially expressed identified by sequencing analysis. observation will ultimately pave future studies focused on analyzing biomarkers larger cohorts ethnically diverse patients. Citation Format: Salma Khan, TessaRae Stiff, Jennifer Simpson, James C. Lynch, Patrick Leaf, Amber Gonda, saeid mirshahidi, Tino Sanchez, Carlos A. Casiano, Nathan R. Wall. [abstract]. In: Proceedings Eighth AACR Conference The Science Health Disparities Racial/Ethnic Minorities Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B13.